Vancomycin pharmacokinetic model development in patients on intermittent online hemodiafiltration
نویسندگان
چکیده
منابع مشابه
A Physiologically-Based Pharmacokinetic Model for Vancomycin
A Physiologically-Based Pharmacokinetic Model for Vancomycin
متن کاملQuality of Life on Online Hemodiafiltration (HDF)
Online hemodiafiltration (OL-HDF) as a renal replacement therapy is gaining momentum due to the perceived added benefit from enhanced clearance of potential‐ ly harmful middle molecules. Favorable effect of OL-HDF on all-cause mortality and cardiovascular mortality and morbidity has been suggested by some clinical trials. Health-related quality of life (HRQOL) is an important component of hemod...
متن کاملCost-Effectiveness of Online Hemodiafiltration
Care of patients with end-stage renal disease (ESRD) is essential but also resource intense. We review several studies on online hemodiafiltration (OL-HDF), which concluded that high-volume OL-HDF is associated with better outcome compared to conventional hemodialysis. The cost-effectiveness of OL-HDF was shown in many studies. For example, in the Canadian setting of the Convective Transport St...
متن کاملPredictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates
INTRODUCTION The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Utilization of population pharmacokinetic models and Bayesian methods offers the potential for developing individualized therapeu...
متن کاملPopulation pharmacokinetic analysis of vancomycin in patients with hematological malignancies.
This study determines vancomycin (VAN) population pharmacokinetics (PK) in adult patients with hematological malignancies. VAN serum concentration data (n = 1,004) from therapeutic drug monitoring were collected retrospectively from 215 patients. A one-compartment PK model was selected. VAN pharmacokinetics population parameters were generated using the NONMEM program. A graphic approach and st...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0216801